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The Source of AIDS
Less than 20 years ago, AIDS came seemingly out of nowhere and developed into a global epidemic. AIDS came from somewhere, of course, but scientists have had great difficulty tracking down its origin. An international team led by Feng Gao of the University of Alabama at Birmingham may have found the answer. Based on extensive field work and genetic studies, they conclude that HIV-1, the main AIDS virus, is closely related to a virus that infects one specific kind of chimpanzee: Pan troglodytes troglodytes, a subspecies that lives in the same part of Africa where AIDS first appeared in humans. The chimp virus has evolved so that it does not kill its host. When the virus jumped to humans, however, it proved lethal. HIV now infects 35 million people around the world.
Nobody knows how HIV first crossed the species barrier. But widespread hunting and butchering of chips in Africa means that people are continuing to expose themselves to the simian virus. The plummeting chimpanzee population also means scientists may not have long to study the natural evolution of the virus, which could assist in the search for a vaccine for AIDS. A meeting of the American Zoological Association later this month will discuss how to save the wild chips. The new findings also raise concern about the possibility that transplanting animal organs into humans (a practice called xenotransplantation) might accidentally bring other diseases along for the ride. Gao's report, along with a related commentary, appears in the February 4 issue of Nature.
--Corey S. Powell
Posted 2/4/99
Discover Magazine
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